Pathology Trivia Question Bank
Surgical Pathology
Author:
Sepi
Submit Date:
8/12/2007
Question:
What is the cause of the characteristic "ground-glass" appearance of hepatocytes in HBV infection?
Answer
:
The 22-nm-diameter HBV surface antigen particles accumulate in the ER. ER expands to accommodate the increased particles. The hepatocytes become enlarged, hydropic, and eosinophilic and display the characteristic features of "ground-glass" cells.
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