Pathology Trivia Question Bank
Surgical Pathology
Author:
J. Kneile
Submit Date:
9/21/2006
Question:
Cowden syndrome is an autosomal dominant condition resulting in hamartomatous neoplasms of the skin, GI tract, bones, CNS, eyes and genitourinary tract. Can you name the gene that is mutated in the majority of Cowden syndrome cases?
Answer
:
The majority of Cowden syndrome cases (70-80%) are due to a mutaion in the PTEN, a tumor suppressor gene located on chromosome 10.
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