Xue-Feng Bai, Ou Li, Qunmin Zhou, Huiming Zhang, Pramod S Joshi, Xincheng Zheng, Yan Liu, Yin Wang, Pan Zheng and Yang Liu. (2004) CD24 controls expansion and persistence of autoreactive T cells in the central nervous system during experimental autoimmune encephalomyelitis. J Exp Med 200: 447-458.
Pramod S. Joshi, Jin-Qing Liu, Yin Wang, Xing Chang, John Richards, Fu-Dong Shi, Erika Assarsson, Hans-Gustaf Ljunggren, and Xue-Feng Bai. (2006) Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms. J Leukoc Biol 80: 1345-1353.
Xue-Feng Bai#, Jin-Qing Liu, Pramod S. Joshi, Lizhong Wang, Lijie Yin, Jadwiga Labanowska, Nyla Heerema, Pan Zheng and Yang Liu. (2006) Different Lineages of P1A-Expressing Cancer Cells Use Divergent Modes of Immune Evasion for T-Cell Adoptive Therapy. Cancer Res. 66(16):8241-9. (# corresponding author.)
Jin-Qing Liu, Joseph Carl Jr., Pramod S. Joshi, Abhik RayChaudhury, Xin-An Pu, Fu-Dong Shi and Xue-Feng Bai. (2007) CD24 on the resident cells in the central nervous system enhances experimental autoimmune encephalomyelitis. J Immunol 178: 6227-6235.
Jin-Qing Liu and Xue-Feng Bai. (2008) Overcoming immune evasion in T cell therapy of cancer: lessons from animal models. Curr Mol Med Feb;8(1):68-75. (review)
Joseph W. Carl Jr., Jin-Qing Liu, Pramod S. Joshi, Lijie Yin, Xincheng Zheng, Caroline C. Whitacre, Yang Liu and Xue-Feng Bai. (2008) Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway. J Immunol 181(1):320-328.
Our laboratory studies the pathogenic mechanisms in immune-mediated diseases. We are particularly interested in T lymphocyte responses in autoimmune diseases and cancer. In autoimmune diseases such as multiple sclerosis, aberrant activation of T lymphocytes leads to their attack of the central nervous system (CNS). Very complicated mechanisms are involved in the disease process, we are mainly focusing on the investigation of the pathological events that leads to T cell generation, activation and invasion of the CNS using various genetic models.
Cytotoxic T lymphocytes (CTL) are the major effectors for the attack of cancer. However, large established tumors are rarely controlled by CTL therapy. Our laboratory investigates the underlie mechanisms of tumor immune evasion during T cell therapy, and develops novel strategies to counter-react immune evasion.