Manuscript “Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells” from Ganju laboratory is being published in J Leucocyte Biol 2007 and was selected to be included among the manuscripts highlighted as Pivotal Advance. Research Grants and Contracts Awarded The Department of Pathology received $7,448,661 in research funds for 43 grants during the 2006-2007 academic year. The department’s research focus is in image analysis, tissue procurement and banking, tumor biology and metastasis, UV carcinogenesis, tumor cytogenetics, and virology and bacterial pathogenesis. P.I. Title Sponsor Amount ($) Ayers Cooperative Tissue Bank of HIV Positive Malignancies National Cancer Institute 1,268,091 Bai Novel Strategies to overcome antigen drift Ohio Cancer Research Assoc. 25,000 Bai CD24 & Experimental autoimmune encephalomyelitis Nat Multiple Sclerosis Society 90,984 Barsky The Bone Marrow Stem Cell Origin of Human Breast Cancer Using Transgenic Mouse Models Department of Defense 112,500 Frankel Chemoprevention of GI tract cancers with berries Coop state res edu& extensive 6,950 Frankel Cooperative human tissue network National Cancer Institute 865,160 Heerema Acute Lymphoblastic Leukemia FISH Reference Children’s Research Institute 43,226 Heerema Children’s Oncology Group Cytogenetic Studies Fndn for the Children’s Oncology Group 77,452 Heerema Minimal residual disease in Ped ALL relation to other prognosis Children’s Research Institute 30,948 Jewell Epigenetic Changes in Mesothelioma National Cancer Institute 59,439 Jewell Gemcitabine plus bevacizumab vs single agent gem. In patients with advanced pancreatic cancer Cancer & Leukemia Group B (CALGB) Foundation 35,305 Jewell Tumor markers to predict treatment response Univ of NC 16,109 Jewell Stress,immune system basal cell carcinoma National Cancer Institute 19,871 Jewell CALGB path coordinating office (PCO) Base funding Univ of Chicago 590,019 Jewell CALGB path coordinating office (PCO) Base funding Univ of Chicago 94,210 Jewell CALGB90203:phase III study Univ of Chicago 25,481 P.I. Title Sponsor Amount ($) Jewell Cancer & leukemia GroupB pathology coord Univ of Chicago 406,785 Lasky Engineered hematopoietic cell self renewal and death Nat heart Lung and Blood Institute 214,476 Lasky Commercialization of a 3D modular perfusion bioreactor system for lab use Case Western 300,000 Liu Tumor burden T cell immunity National Cancer Institute 270,783 Morrison Cooperative human tissue network National Cancer Institute 866,397 Oberyszyn UVB Mouse Model and Effects of Propriety Pharmaceutical Materials Anacor Pharmaceuticals Inc 4,946 Oberyszyn UVB mouse model and effects of proprietary pharm materials Anacor Pharmaceuticals Inc 12,625 Oberyszyn Therapeutic immunosuppression, inflammation and skin cancer National Cancer Institute 251,966 Pancholi, P Clinical evaluation of XPERT SA/MRSA assay Cepheid 67,820 Pancholi, P WAVE-Based Mutation Analysis for Muscular Dystrophy Wyeth Pharmaceuticals 14,938 Prior Sen Paul Wellstone MD Coop research center Seattle University of Washington 300,000 Sedmak Bacterial sepsis oand reactivity of latent Cytomega Nat Inst Gen Medical Scis 13,846 Shen CpG Island Methylator Phen in breast cancer National Cancer Institute 13,617 Wakely Genomic scanning for generic & epigenetic alterations in head&neck cancer Nat Inst dental & Craniofacial 36,375 Waldman Chemoprevention of GI tract cancers with berries Nat Inst Allergy&Infectious Disease 3,000 Waldman CMV disruption of constitutive MHC class II Nat Inst Allergy&Infectious Disease 3,090 Waldman Role of surface chemistry in toxicological properties EPA 60,029 Wu Alveolar macrophage proteomics in HIV induced emphysema Nat Heart Lung & Blood Inst 160,585 Wu Alveolar macrophage proteomics in HIV induced emphysema Nat Heart Lung & Blood Inst 155,928 Wu Intracellular pathways of monocyte survival Nat Heart Lung & Blood Inst 18,750 Wu Eval & validation of SELDI based diag tests for thrombotic purpura Nat Heart Lung & Blood Inst 209,300 Yates Integrative training in biomedical systems Nat Inst Gen Medical Scis 196,459 Yates Integrative training in biomedical systems Nat Inst Gen Medical Scis 157,167 Zou Role and therapeutic potential of Cdk4/6 in B-lymphoma National Cancer Institute 349,034 Total $7,448,661 University-Industry Collaborations One emphasis of our experimental program is to develop University-Industry relationships. In the past year we have established a number of University-Industry partnerships and sponsorships of departmental research. We anticipate expanding these in the coming year. P.I. Title Sponsor Amount ($) Jimenez, R Genomic Markers Prognostic for Recurrence Risk in Women with ER/PR-Negative Invasive Ductal Carcinoma Exagen Diagnostics $50,000 Lozanski, G Quantitative CD52 Flow Analysis for CLL and ALL Clinical CALGB Studies Genzyme Corporation $64,000 Pancholi, P Validation of the VERSANT HIV-1 RNA 3.0 Assay (bDNA) using the VERSANT 440 Molecular System Bayer HealthCare LLC $24,375 Pancholi, P Clinical Evaluation of the XPERT SA/MRSA Assay Cepheid $84,775 Pancholi, P Multidrug Resistant Acinetobacter baumannii Synergy Testing Wyeth Pharmaceuticals $29,875 Wu, H Evaluation and Validation of SELDI-based Diagnostic Test Ciphergen Biosystems, Inc. $150,000