Laboratory of Dr. Haifeng M. Wu

 

Click here to visit the Biomarker Reference Lab website

 

Click here to view recent publications

 

Our Research (click to learn more!)

Our favorite Links

Swiss-2D Find proteins by clicking on 2D gel spots

Swiss-Prot Public protein database

 

 

Our People (click to learn more!)

Protein Analysis Tools and Links

Center For Biological Sequence Analysis-A large number of good prediction algorithms for post translational modifications and protein sorting

TESS Transcription Element Search System

NCBI BLAST- Find proteins (or nucleotides) homologous to a protein (or nucleotide) sequence of interest

BLAT Blast-Like Alignment Tool

First EF First-exon and promoter program for Human DNA

PredictProtien Structure prediction and sequence analysis

Primary DNA-Protien sequence Databases   Bioinformatics Tools for Protein Structure Analysis and Visualisation

Binding sites analysis- A collection of tools for analysing protein binding sites

Mascot- Mass Spectrometry oriented database mining tools for Protien ID

Profound- Mass Spectrometry oriented database mining tools for Protien ID

FindMod -Post-translational modification detection based on MALDI data

FindPept- Nonspecific cleavage, Specific Contamination cleavage, and post-translational modification detection based on MALDI data

Area of Expertise

Hemostasis and Thrombosis, Biomarker development and validation, Clinical Proteomics, Monocyte/macrophage Biology

Interest and Subspecialty

There are four research areas in Dr. Wu’s laboratory

a) Basic Biology of thrombosis, hemostasis, and vascular biology

b) Translational Research in Thrombotic Thrombocytopenic Purpura (TTP): Major goal is to understand the pathophysiology of TTP and to develop novel clinical utilities in early diagnosis and in evaluation of TTP’s disease activity.

c) Clinical Application of Plasma Microparticles (MPs): MPs are cell vesicles/fragments derived from activated/injured/necrotic/cancer cells. Major goal is to discover the biomarkers for evaluating disease process, for early diagnosis and for prediction of diseases.

d) Mononuclear Phagocytes: Goal is to apply proteomics to understand the biology of monocyte to macrophage differentiation and to study the roles of macrophages in disease processes.

 

Ohio State

Medical Center

College of Medicine and Public Health

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