Intra-vascular clotting is the primary cause of many life threatening diseases, such as AMI (Heart Attack), stroke, and DIC (disseminated intravascular coagulation).  Tissue factor (TF) is a membrane protein expressed in virtually all cell types not exposed to circulating blood. When active TF is exposed to blood, clotting occurs.  The only circulating cell that expresses TF is the monocyte.  Normally monocyte TF is encrypted (inactive).  However certain conditions cause TF to de-encrypt,  causing clotting, this often results in one of the previously mentioned diseases. Thus understanding the regulation of TF activity in the monocyte is very important.  We have three different proteomic techniques to help us discover the proteins involved in this process.

Click Here for an example of Functional Proteomics

Click Here for an Example of Phospho-Specific Proteomics

Click Here for an Example of Sub-proteomics