Feb. 7 Growth Factors
and Intracellular Signaling
Sissy Jhiang, Ph.D.,
Internal Medicine
Reading Assignment
The Discovery of receptor tyrosine kinases: targets for cancer
Cell Signaling by Receptor Tyrosine Kinases
The RET proto-oncogene in human cancers
|
Feb. 10
Genetic Testing
Gail Wenger, Ph.D., Pathology
Reading Assignment
Neuroblastoma: Biological insights into a clinical enigma
Genomic Alterations and Chromosomal Aberrations in Human Cancer, Chapter
8, Cancer Biology, pp. 106-111.
Articles for additional reading:
High-resolution detection and mapping of genomic DNA alterations in
neuroblastoma
Chromosome 1p and 11q deletions and outcome in neuroblastoma
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Feb. 14
Genetic Basis of Cancer
Stephen Qualman, M.D., Pathology
Reading Assignment
Genomic Alterations and Chromosomal Aberrations in Human Cancer, Chapter
8, Cancer Biology
Molecular Genetics in the Diagnosis and Prognosis of Solid Pediatric
Tumors (handout, not available online)
Power Point
Presentation
|
Feb. 17
Cancer Cytogenetics
Nyla Heerema, Ph.D., Pathology
Reading Assignment
Genomic Alterations and Chromosomal Aberrations in Human Cancer, Chapter
8, Cancer Biology, pp. 112-120
Power Point Presentation
|
Feb. 21
Tumor Growth and Cell Kinetics
Dale Vandre, Ph.D., Physiology & Cell Biology
Reading Assignment
The Universal Dynamics of Tumor Growth, Biophys J, 85: 2948-2961, 2003
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Feb. 24
Tumor Immunology
Xue-Feng Bai, Ph.D., Pathology
Reading Assignment
Cancer Regression and Autoimmunity in Patients after Clonal Repopulation
with Antitumor Lymphocytes. Science 2002; 298: 850-854.
Antigenic Drift as a Mechanism for Tumor Evasion of Destruction by
Cytolytic T Lymphocytes. J Clin Invest 2003; 111: 1487-1496.
Power Point Presentation
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Feb. 28
Invasion and Metastasis
Sanford Barsky, M.D., Pathology
Reading
Assignment
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Feb. 28
Tumor Angiogenesis
Rolf Barth, M.D., Pathology
Reading
Assignment
Fundamental
concepts of the angiogenic process. Current Molecular Medicine 3:
643-651, 2003.
Angiogenesis: A
target for cancer therapy. Current Pharmaceutical Design 10:
11-26, 2004.
Are
tumours angiogenesis-dependent? J Pathology 202: 5-13, 2004.
Bevacizumab (Avastin), a
humanized anti-VEGF monoclonal antibody for cancer therapy.
Biochemical and Biophysical Research Communications 333: 328-335, 2005.
Tumor Angiogenesis Outline
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March 3
Hormones and Cancer
Charles Capen, D.V.M., Ph.D., Veterinary Biosciences
Reading Assignment
Capen, Charles C. Mechanistic Data and Risk Assessment of Selected
Toxic End Points of the Thyroid Gland. Toxicologic Pathology 25:
39-48, 1997. (Not available online, handout)
Cancer after Nuclear Fallout: Lessons from the Chernobyl Accident.
Nature Reviews 2: 543-549, 2002.
Health Implications of Perchlorate Ingestion. National Research
Council of National Academies, 2005. (Not available online,
handout)
Seeping Threat:
A Fuel of Cold War Defenses Now Ignites Health Controversy. The
Wall Street Journal. December 16, 2002.
Hypercalcemia of Malignancy. Am. J. Med. 103: 134-145, 1997.
The Physiology of Parathyroid Hormone-Related Protein. The New
England Journal of Medicine 342: 177-185, 2000.
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March 7
Experimental Radiotherapy
Steven D'Ambrosio, Ph.D., Radiology
Radiosensitivity Enhancement by Celecoxib, a Cyclooxygenase (COX)-2
Selective Inhibitor, etc., Cancer Research 2005: 65 (20), pp.
9501-9509
Power Point Presentation
|
March 7
Gene Therapy
Sissy Jhiang, Ph.D., Internal Medicine
Reading Assignment
Cancer Gene Therapy: Fringe or Cutting Edge
A "new" reporter in the field of imaging reporter genes:
correlating gene expression and function of the sodium/iodide symporter
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March 10
Biological and Pharmacological Properties of Anti-Cancer Drugs
Michael Grever, M.D., Internal Medicine
Reading
Assignment
Book Chapter: Cancer, Principles and Practice of Oncology, 6th
Edition, Vol. 1, Chapter 19, Pharmacology of Cancer Chemotherapy, pp.
335-362. (Not available online) |